|
T39250 |
Bevurogant
|
|
ROR
|
|
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases. |
|
T16832 |
S18-000003
|
|
ROR
|
|
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. |
|
T4670 |
SR0987
|
|
ROR
|
|
SR0987 is a RORγt agonist, |
|
T5163 |
SR1001
|
|
ROR
|
|
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). |
|
TQ0007 |
Cintirorgon
|
LYC-55716 |
ROR
|
|
Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells. |
|
T4594 |
SR1078
|
SR 1078 |
ROR
|
|
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. |
|
T7388 |
GSK805
|
|
ROR
|
|
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi... |
|
T9635 |
Cedirogant
|
ABBV-157 |
ROR
|
|
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study. |
|
T12753 |
RORγt Inverse agonist 6
|
|
ROR
|
|
|
|
T5160 |
SR3335
|
ML 176 |
ROR
|
|
SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). |
|
T14369 |
AZD-0284
|
|
ROR
|
|
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. |
|
T9623 |
RORγt inverse agonist 13
|
|
ROR
|
|
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. |
|
T4050 |
GSK2981278
|
ROR gama modulator 1 |
ROR
|
|
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
|
T6690 |
T0901317
|
|
Apoptosis
,
FXR
,
Liver X Receptor
,
ROR
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). |
